Follicle Stimulating Hormone and Anti-Mullerian Hormone Among Fertile and Infertile Women in Ile-ife, Nigeria: is There a Difference?
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Abstract:
Background Reduced ovarian reserve has been known to predict poor ovarian response and poor success rates in infertile women undergoing assisted reproductive technology. Ovarian reserve also decreases with age but the rate of decline defers from a woman to another. The aim of this study was to detect any difference in ovarian reserve as measured by basal serum FSH and AMH between matched cohort of fertile and subfertile regularly menstruating women between the ages 18 and 45 years. MaterialsAndMethods This was a case-control study that involved 64 fertile women and 64 subfertile women, matched by age at recruitment. Peripheral blood samples were taken from the women recruited from the Gynaecological clinic and outpatient clinic of Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria. Serum FSH and AMH were quantified using ELISA at the Metabolic Research Laboratory of LAUTECH Teaching Hospital, Ogbomoso, Nigeria. Results There was significant difference in the mean Follicle stimulating hormone (6.97±3.34 vs 13.34± 5.24, p= 0.013) and anti-Müllerian hormone (2.71± 1.91 vs 1.60±2.51, p = 0.029) between the fertile women and the infertile women. There was a negative correlation between FSH and AMH in both groups; fertile women (r = -0.311, p = 0.01) and infertile women (r =-0.374, p = 0.002). Conclusion The difference in ovarian reserve observed in this study suggests that reduced ovarian reserve in regularly menstruating women may be associated with early ovarian ageing or subfertility.
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follicle stimulating hormone and anti-mullerian hormone among fertile and infertile women in ile-ife, nigeria: is there a difference?
background: reduced ovarian reserve has been known to predict poor ovarian response and poor success rates in infertile women undergoing assisted reproductive technology. ovarian reserve also decreases with age but the rate of decline defers from a woman to another. the aim of this study was to detect any difference in ovarian reserve as measured by basal serum fsh and amh between matched cohor...
full textFollicle Stimulating Hormone and Anti-Müllerian Hormone among Fertile and Infertile Women in Ile-Ife, Nigeria: Is there A Difference?
BACKGROUND Reduced ovarian reserve predicts poor ovarian response and poor suc- cess rates in infertile women who undergo assisted reproductive technology (ART). Ovarian reserve also decreases with age but the rate of decline varies from one woman to another. This study aims to detect differences in ovarian reserve as measured by basal serum follicle stimulating hormone (FSH) and anti-Müllerian...
full textAge-Specific Serum Anti-Mullerian Hormone and Follicle Stimulating Hormone Concentrations in Infertile Iranian Women
Background Anti-Müllerian hormone (AMH) is secreted by the granulosa cells of growing follicles during the primary to large antral follicle stages. Abnormal levels of AMH and follicle stimulating hormone (FSH) may indicate a woman’s diminished ability or inability to conceive. Our aim is to investigate the changes in serum AMH and FSH concentrations at different age groups and its correlation w...
full textThe Correlations of Anti-Mullerian Hormone, Follicle-Stimulating Hormone and Antral Follicle Count in Different Age Groups of Infertile Women
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Age-specific nomograms for follicle stimulating hormone and anti-Mullerian hormone: A pilot study in Ile-Ife, Nigeria
BACKGROUND Assessment of ovarian reserve is one of the steps in the management of infertile couples. Follicle Stimulating hormone (FSH) and anti-Müllerian hormone (AMH) are commonly used ovarian reserve markers in Africa. However, there is paucity of age-specific reference values for FSH and AMH among the African population. OBJECTIVE This study aimed at conducting a pilot study for generatio...
full textAge-Specific Serum Anti-Mullerian Hormone and Follicle Stimulating Hormone Concentrations in Infertile Iranian Women
BACKGROUND Anti-Müllerian hormone (AMH) is secreted by the granulosa cells of growing follicles during the primary to large antral follicle stages. Abnormal levels of AMH and follicle stimulating hormone (FSH) may indicate a woman's diminished ability or inability to conceive. Our aim is to investigate the changes in serum AMH and FSH concentrations at different age groups and its correlation w...
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Journal title
volume 11 issue 1
pages 33- 39
publication date 2017-04-01
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